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Enalaprilat Dihydrate

CAS No. 84680-54-6

Enalaprilat Dihydrate( —— )

Catalog No. M16146 CAS No. 84680-54-6

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Enalaprilat Dihydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
  • Description
    Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.(In Vitro):Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.(In Vivo):Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
  • In Vitro
    Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.
  • In Vivo
    Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    ACE
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    84680-54-6
  • Formula Weight
    348.4
  • Molecular Formula
    C18H24N2O5.2H2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:70 mg/mL (200.91 mM)； Ethanol:<1 mg/mL (<1 mM)； Water:<1 mg/mL (<1 mM)
  • SMILES
    O.O.C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r,c:8,10,t:6|
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.
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